Identifying DNA-binding proteins by combining support vector machine and PSSM distance transformation.

ABSTRACT:

Background

DNA-binding proteins play a pivotal role in various intra- and extra-cellular activities ranging from DNA replication to gene expression control. Identification of DNA-binding proteins is one of the major challenges in the field of genome annotation. There have been several computational methods proposed in the literature to deal with the DNA-binding protein identification. However, most of them can't provide an invaluable knowledge base for our understanding of DNA-protein interactions.

Results

We firstly presented a new protein sequence encoding method called PSSM Distance Transformation, and then constructed a DNA-binding protein identification method (SVM-PSSM-DT) by combining PSSM Distance Transformation with support vector machine (SVM). First, the PSSM prof

SUBMITTER: Xu R 

PROVIDER: S-EPMC4331676 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature