Depressive symptoms and short telomere length are associated with increased mortality in bladder cancer patients.

ABSTRACT:

Background

Depression is associated with an increased risk of mortality in patients with cancer; it has been hypothesized that depression-associated alterations in cell aging mechanisms, in particular, the telomere/telomerase maintenance system, may underlie this increased risk. We evaluated the association of depressive symptoms and telomere length to mortality and recurrence/progression in 464 patients with bladder cancer.

Methods

We used the Center for Epidemiologic Studies Depression Scale (CES-D) and Structured Clinical Interview for DSM-IV Disorder (SCID) to assess current depressive symptoms and lifetime major depressive disorder (MDD), respectively, and telomere length was assessed from peripheral blood lymphocytes. Multivariate Cox regression was used to assess the

SUBMITTER: Lin J 

PROVIDER: S-EPMC4332382 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature