Multiplex Screen of Serum Biomarkers in Facioscapulohumeral Muscular Dystrophy.

ABSTRACT:

Background

Recent studies have proposed a unified genetic model for Facioscapulohumeral muscular dystrophy (FSHD), identifying potential therapeutic targets for future clinical trials. Serum biomarkers related to disease activity will be important for proof of concept or early phase clinical studies.

Objective

To identify potential serum biomarkers in FSHD for possible use in future clinical trials.

Methods

We performed a prospective cross-sectional study of serum biomarkers in 22 FSHD patients (19 FSHD1, 3 FSHD2) compared to 23 age and gender-matched healthy controls using a commercial multiplex, microsphere-based immune-fluorescent assay of 243 markers (Myriad, Human Discovery MAP 250, v2.0).

Results

169 markers had values sufficient for analysis. Correction

SUBMITTER: Statland J 

PROVIDER: S-EPMC4332410 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature