Association of type 2 diabetes genetic variants with breast cancer survival among Chinese women.

ABSTRACT:

Objective

To evaluate whether the genetic susceptibility of T2D was associated with overall survival (OS) and disease-free survival (DFS) outcomes for breast cancer (BC).

Methods

Included in the study were 6346 BC patients who participated in three population-based epidemiological studies of BC and were genotyped with either GWAS or Exome-chip. We constructed a genetic risk score (GRS) for diabetes using risk variants identified from the GWAS catalog (http://genome.gov/gwastudies) that were associated with T2D risk at a minimum significance level of P ≤ 5.0E-8 among Asian population and evaluated its associations with BC outcomes with Cox proportional hazards models.

Results

During a median follow-up of 8.08 years (range, 0.01-16.95 years), 1208 deaths were documented

SUBMITTER: Bao PP 

PROVIDER: S-EPMC4332504 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature