Large scale aggregate microarray analysis reveals three distinct molecular subclasses of human preeclampsia.

ABSTRACT:

Background

Preeclampsia (PE) is a life-threatening hypertensive pathology of pregnancy affecting 3-5% of all pregnancies. To date, PE has no cure, early detection markers, or effective treatments short of the removal of what is thought to be the causative organ, the placenta, which may necessitate a preterm delivery. Additionally, numerous small placental microarray studies attempting to identify "PE-specific" genes have yielded inconsistent results. We therefore hypothesize that preeclampsia is a multifactorial disease encompassing several pathology subclasses, and that large cohort placental gene expression analysis will reveal these groups.

Results

To address our hypothesis, we utilized known bioinformatic methods to aggregate 7 microarray data sets across multiple platfo

SUBMITTER: Leavey K 

PROVIDER: S-EPMC4332506 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature