Development of potent inhibitors of pyocyanin production in Pseudomonas aeruginosa.

ABSTRACT: The development of new approaches for the treatment of antimicrobial-resistant infections is an urgent public health priority. The Pseudomonas aeruginosa pathogen, in particular, is a leading source of infection in hospital settings, with few available treatment options. In the context of an effort to develop antivirulence strategies to combat bacterial infection, we identified a series of highly effective small molecules that inhibit the production of pyocyanin, a redox-active virulence factor produced by P. aeruginosa. Interestingly, these new antagonists appear to suppress P. aeruginosa virulence factor production through a pathway that is independent of LasR and RhlR.

SUBMITTER: Miller LC 

PROVIDER: S-EPMC4332565 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature