Combined liquid chromatography-tandem mass spectrometry analysis of progesterone metabolites.

ABSTRACT: Progesterone has a number of important functions throughout the human body. While the roles of progesterone are well known, the possible actions and implications of progesterone metabolites in different tissues remain to be determined. There is a growing body of evidence that these metabolites are not inactive, but can have significant biological effects, as anesthetics, anxiolytics and anticonvulsants. Furthermore, they can facilitate synthesis of myelin components in the peripheral nervous system, have effects on human pregnancy and onset of labour, and have a neuroprotective role. For a better understanding of the functions of progesterone metabolites, improved analytical methods are essential. We have developed a combined liquid chromatography-tandem mass spectrometry (LC-MS/MS) method

SUBMITTER: Sinreih M 

PROVIDER: S-EPMC4332660 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature