Prenatal stress down-regulates Reelin expression by methylation of its promoter and induces adult behavioral impairments in rats.

ABSTRACT: Prenatal stress causes predisposition to cognitive and emotional disturbances and is a risk factor towards the development of neuropsychiatric conditions like depression, bipolar disorders and schizophrenia. The extracellular protein Reelin, expressed by Cajal-Retzius cells during cortical development, plays critical roles on cortical lamination and synaptic maturation, and its deregulation has been associated with maladaptive conditions. In the present study, we address the effect of prenatal restraint stress (PNS) upon Reelin expression and signaling in pregnant rats during the last 10 days of pregnancy. Animals from one group, including control and PNS exposed fetuses, were sacrificed and analyzed using immunohistochemical, biochemical, cell biology and molecular biology approaches. We

SUBMITTER: Palacios-Garcia I 

PROVIDER: S-EPMC4332679 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature