Optical imaging of disrupted functional connectivity following ischemic stroke in mice.

ABSTRACT: Recent human neuroimaging studies indicate that spontaneous fluctuations in neural activity, as measured by functional connectivity magnetic resonance imaging (fcMRI), are significantly affected following stroke. Disrupted functional connectivity is associated with behavioral deficits and has been linked to long-term recovery potential. FcMRI studies of stroke in rats have generally produced similar findings, although subacute cortical reorganization following focal ischemia appears to be more rapid than in humans. Similar studies in mice have not been published, most likely because fMRI in the small mouse brain is technically challenging. Extending functional connectivity methods to mouse models of stroke could provide a valuable tool for understanding the link between molecular mechanism

SUBMITTER: Bauer AQ 

PROVIDER: S-EPMC4332714 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature