Sarcopenia adversely impacts postoperative complications following resection or transplantation in patients with primary liver tumors.

ABSTRACT:

Background

Sarcopenia is a surrogate marker of patient frailty that estimates the physiologic reserve of an individual patient. We sought to investigate the impact of sarcopenia on short- and long-term outcomes in patients having undergone surgical intervention for primary hepatic malignancies.

Methods

Ninety-six patients who underwent hepatic resection or liver transplantation for HCC or ICC at the John Hopkins Hospital between 2000 and 2013 met inclusion criteria. Sarcopenia was assessed by the measurement of total psoas major volume (TPV) and total psoas area (TPA). The impact of sarcopenia on perioperative complications and survival was assessed.

Results

Mean age was 61.9 years and most patients were men (61.4 %). Mean adjusted TPV was lower in women (23.3 cm(3)/m

SUBMITTER: Valero V 

PROVIDER: S-EPMC4332815 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature