Type 2 diabetes risk variants and colorectal cancer risk: the Multiethnic Cohort and PAGE studies.

ABSTRACT:

Background

Diabetes has been positively associated with the risk of colorectal cancer. This study investigated whether recently established risk variants for diabetes also have effects on colorectal cancer.

Methods

19 single nucleotide repeats (SNPs) associated with type 2 diabetes in genome-wide association studies were tested in a case-control study of 2011 colorectal cancer cases and 6049 controls nested in the Multiethnic Cohort study as part of the Population Architecture using Genomics and Epidemiology (PAGE) initiative. ORs and 95% CIs were estimated by unconditional logistic regression to evaluate the association between SNPs and colorectal cancer risk, adjusting for age, sex and race/ethnicity. Permutation testing was conducted to correct for multiple hypothesis tes

SUBMITTER: Cheng I 

PROVIDER: S-EPMC4332884 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature