Impact of antipsychotic treatment on attention and motor learning systems in first-episode schizophrenia.

ABSTRACT:

Background

Antipsychotic medications have established clinical benefit, but there are few neuroimaging studies before and after initiating antipsychotic medication to assess drug influence on brain circuitry. Attention and motor learning tasks are promising approaches for examining treatment-related changes in frontostriatal systems.

Methods

Twenty-one unmedicated first-episode schizophrenia patients (14 antipsychotic-naïve) participated in functional imaging studies while performing visual attention (prosaccades) and motor learning tasks (predictive saccades). Posttreatment testing was completed in 14 patients after 4-6 weeks of antipsychotic treatment. Matched healthy controls were studied in parallel.

Results

Pretreatment, patients had reduced activation in the dor

SUBMITTER: Keedy SK 

PROVIDER: S-EPMC4332935 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature