Functional outcome in people at high risk for psychosis predicted by thalamic glutamate levels and prefronto-striatal activation.

ABSTRACT: Little is known about the neurobiological factors that determine functional outcome in people at high risk for psychosis. We use multimodal neuroimaging to investigate whether cortical responses during a cognitive task and thalamic glutamate levels were associated with subsequent functional outcome. Sixty subjects participated: 27 healthy controls (CTRL) and 33 at ultrahigh risk (UHR) for psychosis. At baseline, cortical responses during a verbal fluency task were measured using functional Magnetic Resonance Imaging (fMRI) and proton Magnetic Resonance Spectroscopy (1H-MRS) was used to measure thalamic glutamate levels. The UHR subjects were then followed clinically for a mean duration of 18 months, and subdivided into "good" and "poor" functional outcome subgroups according to their Globa

SUBMITTER: Allen P 

PROVIDER: S-EPMC4332951 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature