Histologic features of melanoma associated with CDKN2A genotype.

ABSTRACT:

Background

Inherited susceptibility genes have been associated with histopathologic characteristics of tumors.

Objective

We sought to identify associations between histology of melanomas and CDKN2A genotype.

Methods

This was a case-control study design comparing 28 histopathologic tumor features among individuals with sporadic melanomas (N = 81) and cases from melanoma families with (N = 123) and without (N = 120) CDKN2A germline mutations.

Results

Compared with CDKN2A(-) cases, mutation carriers tended to have histologic features of superficial spreading melanoma subtype including higher pigmentation (Ptrend = .02) and increased pagetoid scatter (Ptrend = .07) after adjusting for age at diagnosis, sex, and American Joint Committee on Cancer thickness category.

SUBMITTER: Sargen MR 

PROVIDER: S-EPMC4333073 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature