Homotopic connectivity in drug-naive, first-episode, early-onset schizophrenia.

ABSTRACT:

Background

The disconnection hypothesis of schizophrenia has been extensively tested in adults. Recent studies have reported the presence of brain disconnection in younger patients, adding evidence to support the neurodevelopmental hypothesis of schizophrenia. Because of drug confounds in chronic and medicated patients, it has been extremely challenging for researchers to directly investigate abnormalities in the development of connectivity and their role in the pathophysiology of schizophrenia. The present study aimed to examine functional homotopy - a measure of interhemispheric connection - and its relevance to clinical symptoms in first-episode drug-naïve early-onset schizophrenia (EOS) patients.

Methods

Resting-state functional magnetic resonance imaging was performed i

SUBMITTER: Li HJ 

PROVIDER: S-EPMC4333112 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature