Genome-wide comparative analysis reveals human-mouse regulatory landscape and evolution.

ABSTRACT:

Background

Because species-specific gene expression is driven by species-specific regulation, understanding the relationship between sequence and function of the regulatory regions in different species will help elucidate how differences among species arise. Despite active experimental and computational research, relationships among sequence, conservation, and function are still poorly understood.

Results

We compared transcription factor occupied segments (TFos) for 116 human and 35 mouse TFs in 546 human and 125 mouse cell types and tissues from the Human and the Mouse ENCODE projects. We based the map between human and mouse TFos on a one-to-one nucleotide cross-species mapper, bnMapper, that utilizes whole genome alignments (WGA). Our analysis shows that TFos are under ev

SUBMITTER: Denas O 

PROVIDER: S-EPMC4333152 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature