Prediction of protein-protein interactions related to protein complexes based on protein interaction networks.

ABSTRACT: A method for predicting protein-protein interactions based on detected protein complexes is proposed to repair deficient interactions derived from high-throughput biological experiments. Protein complexes are pruned and decomposed into small parts based on the adaptive k-cores method to predict protein-protein interactions associated with the complexes. The proposed method is adaptive to protein complexes with different structure, number, and size of nodes in a protein-protein interaction network. Based on different complex sets detected by various algorithms, we can obtain different prediction sets of protein-protein interactions. The reliability of the predicted interaction sets is proved by using estimations with statistical tests and direct confirmation of the biological data. In compa

SUBMITTER: Liu P 

PROVIDER: S-EPMC4333188 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature