Unknown

Dataset Information

0

Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma.

ABSTRACT: Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study including 1,854 PACG cases and 9,608 controls across 5 sample collections in Asia. Replication experiments were conducted in 1,917 PACG cases and 8,943 controls collected from a further 6 sample collections. We report significant associations at three new loci: rs11024102 in PLEKHA7 (per-allele odds ratio (OR)=1.22; P=5.33×10(-12)), rs3753841 in COL11A1 (per-allele OR=1.20; P=9.22×10(-10)) and rs1015213 located between PCMTD1 and ST18 on chromosome 8q (per-allele OR=1.50; P=3.29×10(-9)). Our findings, accumulated across these independent worldwide collections, suggest possible mechanisms explaining the pathogenesis of PACG.

SUBMITTER: Vithana EN 

PROVIDER: S-EPMC4333205 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma.

Vithana Eranga N EN   Khor Chiea-Chuen CC   Qiao Chunyan C   Nongpiur Monisha E ME   George Ronnie R   Chen Li-Jia LJ   Do Tan T   Abu-Amero Khaled K   Huang Chor Kai CK   Low Sancy S   Tajudin Liza-Sharmini A LA   Perera Shamira A SA   Cheng Ching-Yu CY   Xu Liang L   Jia Hongyan H   Ho Ching-Lin CL   Sim Kar Seng KS   Wu Ren-Yi RY   Tham Clement C Y CCY   Chew Paul T K PTK   Su Daniel H DH   Oen Francis T FT   Sarangapani Sripriya S   Soumittra Nagaswamy N   Osman Essam A EA   Wong Hon-Tym HT   Tang Guangxian G   Fan Sujie S   Meng Hailin H   Huong Dao T L DTL   Wang Hua H   Feng Bo B   Baskaran Mani M   Shantha Balekudaru B   Ramprasad Vedam L VL   Kumaramanickavel Govindasamy G   Iyengar Sudha K SK   How Alicia C AC   Lee Kelvin Y KY   Sivakumaran Theru A TA   Yong Victor H K VHK   Ting Serena M L SML   Li Yang Y   Wang Ya-Xing YX   Tay Wan-Ting WT   Sim Xueling X   Lavanya Raghavan R   Cornes Belinda K BK   Zheng Ying-Feng YF   Wong Tina T TT   Loon Seng-Chee SC   Yong Vernon K Y VKY   Waseem Naushin N   Yaakub Azhany A   Chia Kee-Seng KS   Allingham R Rand RR   Hauser Michael A MA   Lam Dennis S C DSC   Hibberd Martin L ML   Bhattacharya Shomi S SS   Zhang Mingzhi M   Teo Yik Ying YY   Tan Donald T DT   Jonas Jost B JB   Tai E-Shyong ES   Saw Seang-Mei SM   Hon Do Nhu DN   Al-Obeidan Saleh A SA   Liu Jianjun J   Chau Tran Nguyen Bich TNB   Simmons Cameron P CP   Bei Jin-Xin JX   Zeng Yi-Xin YX   Foster Paul J PJ   Vijaya Lingam L   Wong Tien-Yin TY   Pang Chi-Pui CP   Wang Ningli N   Aung Tin T  

Nature genetics 20120826 10

Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study including 1,854 PACG cases and 9,608 controls across 5 sample collections in Asia. Replication experiments were conducted in 1,917 PACG cases and 8,943 controls collected from a further 6 sample collections. We report significant associations at three new loci: rs11024102 in PLEKHA7 (per-allele odds ratio (OR)=1.22; P=5.33×10(-12)), rs3753841 in COL11A1 (per-allele OR=1.20;  ...[more]

Similar Datasets

Unknown An extensive replication study on three new susceptibility Loci of primary angle closure glaucoma in han chinese: jiangsu eye study.
| S-EPMC3824414 | biostudies-literature
Unknown Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma.
| S-EPMC5985943 | biostudies-literature
Unknown Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma.
| S-EPMC6251544 | biostudies-literature
Unknown Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.
| S-EPMC3150510 | biostudies-literature
Unknown Genotype-ocular biometry correlation analysis of eight primary angle closure glaucoma susceptibility loci in a cohort from Northern China.
| S-EPMC6219795 | biostudies-literature
Unknown Identification of genetic loci associated with primary angle-closure glaucoma in the basset hound.
| S-EPMC4000717 | biostudies-literature
Unknown Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma.
| S-EPMC4731307 | biostudies-literature
Unknown Association of Matrix Metalloproteinase-9 (MMP9) Variants with Primary Angle Closure and Primary Angle Closure Glaucoma.
| S-EPMC4896618 | biostudies-literature
Unknown The genetic mechanisms of primary angle closure glaucoma.
| S-EPMC4815686 | biostudies-literature
Unknown Patient-Reported Vision-Related Quality-of-Life Differences between Primary Angle-Closure Glaucoma and Primary Open-Angle Glaucoma.
| S-EPMC5045164 | biostudies-literature