The roles of post-translational modifications in the context of protein interaction networks.

ABSTRACT: Among other effects, post-translational modifications (PTMs) have been shown to exert their function via the modulation of protein-protein interactions. For twelve different main PTM-types and associated subtypes and across 9 diverse species, we investigated whether particular PTM-types are associated with proteins with specific and possibly "strategic" placements in the network of all protein interactions by determining informative network-theoretic properties. Proteins undergoing a PTM were observed to engage in more interactions and positioned in more central locations than non-PTM proteins. Among the twelve considered PTM-types, phosphorylated proteins were identified most consistently as being situated in central network locations and with the broadest interaction spectrum to proteins

SUBMITTER: Duan G 

PROVIDER: S-EPMC4333291 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature