The sensor histidine kinase RgfC affects group B streptococcal virulence factor expression independent of its response regulator RgfA.

ABSTRACT: Group B streptococci (GBS; Streptococcus agalactiae) are beta-hemolytic, Gram-positive bacteria that are common asymptomatic colonizers of healthy adults. However, these opportunistic bacteria also cause invasive infections in human newborns and in certain adult populations. To adapt to the various environments encountered during its disease cycle, GBS encodes a number of two-component signaling systems. Previous studies have indicated that the TCS comprising the sensor histidine kinase RgfC and the response regulator RgfA mediate GBS binding to extracellular matrix components, such as fibrinogen. However, in certain GBS clinical isolates, a point mutation in rgfA results in premature truncation of the response regulator. The truncated RgfA protein lacks the C-terminal DNA binding domain n

SUBMITTER: Gendrin C 

PROVIDER: S-EPMC4333453 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature