Circulating leukocyte telomere length and risk of overall and aggressive prostate cancer.

ABSTRACT:

Background

Recent large-scale prospective studies suggest that long telomeres are associated with an increase cancer risk, counter to conventional wisdom.

Methods

To further clarify the association between leukocyte telomere length (LTL) and prostate cancer, and assess genetic variability in relation to both LTL and prostate cancer, we performed a nested case-control study (922 cases and 935 controls). The participants provided blood in 1993-1995 and were followed through August 2004 (prostate cancer incidence) or until 28 February 2013 (lethal or fatal prostate cancer). Relative LTL was measured by quantitative PCR and was calculated as the ratio of telomere repeat copy number to a single gene (36B4) copy number (T/S). Genotyping was performed using the TaqMan OpenArray SNP

SUBMITTER: Julin B 

PROVIDER: S-EPMC4333493 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature