EHR-based phenome wide association study in pancreatic cancer.

ABSTRACT:

Background

Pancreatic cancer is one of the most common causes of cancer-related deaths in the United States, it is difficult to detect early and typically has a very poor prognosis. We present a novel method of large-scale clinical hypothesis generation based on phenome wide association study performed using Electronic Health Records (EHR) in a pancreatic cancer cohort.

Methods

The study population consisted of 1,154 patients diagnosed with malignant neoplasm of pancreas seen at The Froedtert & The Medical College of Wisconsin academic medical center between the years 2004 and 2013. We evaluated death of a patient as the primary clinical outcome and tested its association with the phenome, which consisted of over 2.5 million structured clinical observations extracted out of

SUBMITTER: Adamusiak T 

PROVIDER: S-EPMC4333703 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature