The Hippo pathway regulates homeostatic growth of stem cell niche precursors in the Drosophila ovary.

ABSTRACT: The Hippo pathway regulates organ size, stem cell proliferation and tumorigenesis in adult organs. Whether the Hippo pathway influences establishment of stem cell niche size to accommodate changes in organ size, however, has received little attention. Here, we ask whether Hippo signaling influences the number of stem cell niches that are established during development of the Drosophila larval ovary, and whether it interacts with the same or different effector signaling pathways in different cell types. We demonstrate that canonical Hippo signaling regulates autonomous proliferation of the soma, while a novel hippo-independent activity of Yorkie regulates autonomous proliferation of the germ line. Moreover, we demonstrate that Hippo signaling mediates non-autonomous proliferation signals be

SUBMITTER: Sarikaya DP 

PROVIDER: S-EPMC4333732 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature