MiRNA expression in control and FSHD fetal human muscle biopsies.

ABSTRACT: BACKGROUND:Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal-dominant disorder and is one of the most common forms of muscular dystrophy. We have recently shown that some hallmarks of FSHD are already expressed in fetal FSHD biopsies, thus opening a new field of investigation for mechanisms leading to FSHD. As microRNAs (miRNAs) play an important role in myogenesis and muscle disorders, in this study we compared miRNAs expression levels during normal and FSHD muscle development. METHODS:Muscle biopsies were obtained from quadriceps of both healthy control and FSHD1 fetuses with ages ranging from 14 to 33 weeks of development. miRNA expression profiles were analyzed using TaqMan Human MicroRNA Arrays. RESULTS:During human skeletal muscle development, in control muscle biopsies w

SUBMITTER: Portilho DM 

PROVIDER: S-EPMC4333765 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature