Sampled ensemble neutrality as a feature to classify potential structured RNAs.

ABSTRACT:

Background

Structured RNAs have many biological functions ranging from catalysis of chemical reactions to gene regulation. Yet, many homologous structured RNAs display most of their conservation at the secondary or tertiary structure level. As a result, strategies for structured RNA discovery rely heavily on identification of sequences sharing a common stable secondary structure. However, correctly distinguishing structured RNAs from surrounding genomic sequence remains challenging, especially during de novo discovery. RNA also has a long history as a computational model for evolution due to the direct link between genotype (sequence) and phenotype (structure). From these studies it is clear that evolved RNA structures, like protein structures, can be considered robust to point mut

SUBMITTER: Pei S 

PROVIDER: S-EPMC4333902 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature