Sex-specific trans-regulatory variation on the Drosophila melanogaster X chromosome.

ABSTRACT: The X chromosome constitutes a unique genomic environment because it is present in one copy in males, but two copies in females. This simple fact has motivated several theoretical predictions with respect to how standing genetic variation on the X chromosome should differ from the autosomes. Unmasked expression of deleterious mutations in males and a lower census size are expected to reduce variation, while allelic variants with sexually antagonistic effects, and potentially those with a sex-specific effect, could accumulate on the X chromosome and contribute to increased genetic variation. In addition, incomplete dosage compensation of the X chromosome could potentially dampen the male-specific effects of random mutations, and promote the accumulation of X-linked alleles with sexually dim

SUBMITTER: Stocks M 

PROVIDER: S-EPMC4334168 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature