Role of dynamics in enzyme catalysis: substantial versus semantic controversies.

ABSTRACT: CONSPECTUS: The role of the enzyme's dynamic motions in catalysis is at the center of heated contemporary debates among both theoreticians and experimentalists. Resolving these apparent disputes is of both intellectual and practical importance: incorporation of enzyme dynamics could be critical for any calculation of enzymatic function and may have profound implications for structure-based drug design and the design of biomimetic catalysts. Analysis of the literature suggests that while part of the dispute may reflect substantial differences between theoretical approaches, much of the debate is semantic. For example, the term "protein dynamics" is often used by some researchers when addressing motions that are in thermal equilibrium with their environment, while other researchers only use

SUBMITTER: Kohen A 

PROVIDER: S-EPMC4334245 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature