Single-nucleotide polymorphisms of microRNA processing machinery genes and risk of colorectal cancer.

ABSTRACT:

Objective

MicroRNA (miRNA)-related single-nucleotide polymorphisms (miR-SNPs) in miRNA processing machinery genes can affect cancer risk, treatment efficacy, and patient prognosis. We genotyped 6 miR-SNPs of miRNA processing machinery genes including XPO5 (rs11077), RAN (rs14035), Dicer (rs3742330), TNRC6B (rs9623117), GEMIN3 (rs197412), and GEMIN4 (rs2740348) in a case-control study to evaluate their impact on colorectal cancer (CRC) risk.

Materials and methods

miR-SNPs were genotyped using the polymerase chain reaction- ligase detection reaction. The χ (2) test was used to analyze dichotomous values, such as the presence or absence of any individual SNP in CRC patients and healthy controls.

Results

Two of these SNPs were identified for their association with cancer

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC4334349 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature