Injury induces direct lineage segregation of functionally distinct airway basal stem/progenitor cell subpopulations.

ABSTRACT: Following injury, stem cells restore normal tissue architecture by producing the proper number and proportions of differentiated cells. Current models of airway epithelial regeneration propose that distinct cytokeratin 8-expressing progenitor cells, arising from p63(+) basal stem cells, subsequently differentiate into secretory and ciliated cell lineages. We now show that immediately following injury, discrete subpopulations of p63(+) airway basal stem/progenitor cells themselves express Notch pathway components associated with either secretory or ciliated cell fate commitment. One basal cell population displays intracellular Notch2 activation and directly generates secretory cells; the other expresses c-myb and directly yields ciliated cells. Furthermore, disrupting Notch ligand activity

SUBMITTER: Pardo-Saganta A 

PROVIDER: S-EPMC4334442 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature