Roles for endothelin receptor B and BCL2A1 in spontaneous CNS metastasis of melanoma.

ABSTRACT: Metastatic spread of melanoma to the central nervous system (CNS) is a common and devastating manifestation of disease progression, which, despite its clinical importance, remains poorly understood with respect to underlying molecular mechanisms. Using a recently developed preclinical model of spontaneous melanoma CNS metastasis, we have identified alterations in expression of endothelin receptor B (EDNRB) as a potential factor that influences brain metastatic potential. Induced overexpression of this gene mediated enhanced overall metastatic disease, and resulted in an increased incidence of spontaneous CNS metastases. In contrast, the overexpression of other highlighted genes, such as BCL2A1, did not affect the incidence of CNS metastases but nevertheless appears to facilitate intracrani

SUBMITTER: Cruz-Munoz W 

PROVIDER: S-EPMC4334445 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature