Neurite, a finite difference large scale parallel program for the simulation of electrical signal propagation in neurites under mechanical loading.

ABSTRACT: With the growing body of research on traumatic brain injury and spinal cord injury, computational neuroscience has recently focused its modeling efforts on neuronal functional deficits following mechanical loading. However, in most of these efforts, cell damage is generally only characterized by purely mechanistic criteria, functions of quantities such as stress, strain or their corresponding rates. The modeling of functional deficits in neurites as a consequence of macroscopic mechanical insults has been rarely explored. In particular, a quantitative mechanically based model of electrophysiological impairment in neuronal cells, Neurite, has only very recently been proposed. In this paper, we present the implementation details of this model: a finite difference parallel program for simulat

SUBMITTER: Garcia-Grajales JA 

PROVIDER: S-EPMC4334526 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature