Increased bone resorption during tenofovir plus lopinavir/ritonavir therapy in Chinese individuals with HIV.

ABSTRACT:

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We sought to evaluate the effects of antiretroviral therapy on skeletal metabolism in Chinese individuals with human immunodeficiency virus. Patients switched to tenofovir/lamivudine + lopinavir/ritonavir after treatment failure had an increase in bone resorption marker levels by nearly 60%, which is greater than the magnitude previously described in non-Chinese populations.

Introduction

Few studies have evaluated the effects of antiretroviral therapy on skeletal metabolism in Asian populations infected with human immunodeficiency virus (HIV).

Methods

We performed a secondary analysis of bone turnover markers (BTM) at baseline and 2 years in stored plasma samples collected from 2/2009 to 1/2013 as part of a multi-center trial. Two groups were compared: (1)

SUBMITTER: Hsieh E 

PROVIDER: S-EPMC4334679 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature