Mapping genetic contributions to cardiac pathology induced by Beta-adrenergic stimulation in mice.

ABSTRACT:

Background

Chronic stress-induced cardiac pathology exhibits both a wide range in severity and a high degree of heterogeneity in clinical manifestation in human patients. This variability is contributed to by complex genetic and environmental etiologies within the human population. Genetic approaches to elucidate the genetics underlying the acquired forms of cardiomyopathies, including genome-wide association studies, have been largely unsuccessful, resulting in limited knowledge as to the contribution of genetic variations for this important disease.

Methods and results

Using the β-adrenergic agonist isoproterenol as a specific pathological stressor to circumvent the problem of etiologic heterogeneity, we performed a genome-wide association study for genes influencing cardi

SUBMITTER: Rau CD 

PROVIDER: S-EPMC4334708 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature