Blood lipids and colorectal polyps: testing an etiologic hypothesis using phenotypic measurements and Mendelian randomization.

ABSTRACT:

Purpose

Studies linking cholesterol levels to the development of colorectal neoplasia are inconsistent, and Mendelian randomization has been suggested as a way to help avoid problems with confounding and reverse causation.

Methods

We genotyped individuals who received a colonoscopy at Group Health (1998-2007) for 96 of 102 single-nucleotide polymorphisms identified by the Global Lipids Genetics Consortium. Participants included 139 advanced adenoma cases, 518 non-advanced adenoma cases, 380 non-adenomatous polyp cases, and 754 polyp-free controls. All had at least one available pre-colonoscopy lipid measurement from electronic records maintained by Group Health.

Results

Advanced adenoma cases were more likely than controls to have higher pre-colonoscopy zenith low-den

SUBMITTER: Passarelli MN 

PROVIDER: S-EPMC4334709 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature