Simultaneous consideration of multiple candidate protein biomarkers for long-term risk for cardiovascular events.

ABSTRACT:

Background

Although individual protein biomarkers are associated with cardiovascular risk, rarely have multiple proteins been considered simultaneously to identify which set of proteins best predicts risk.

Methods and results

In a nested case-control study of 273 death/myocardial infarction (MI) cases and 273 age- (within 10 years), sex-, and race-matched and event-free controls from among 2023 consecutive patients (median follow-up 2.5 years) with suspected coronary disease, plasma levels of 53 previously reported biomarkers of cardiovascular risk were determined in a core laboratory. Three penalized logistic regression models were fit using the elastic net to identify panels of proteins independently associated with death/MI: proteins alone (Model 1); proteins in a model c

SUBMITTER: Halim SA 

PROVIDER: S-EPMC4334748 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature