Altered expression of the imprinted transcription factor PLAGL1 deregulates a network of genes in the human IUGR placenta.

ABSTRACT: Genomic imprinting is the epigenetic process that results in monoallelic expression of genes depending on parental origin. These genes are known to be critical for placental development and fetal growth in mammals. Aberrant epigenetic profiles at imprinted loci, such as DNA methylation defects, are surprisingly rare in pregnancies with compromised fetal growth, while variations in transcriptional output from the expressed alleles of imprinted genes are more commonly reported in pregnancies complicated with intrauterine growth restriction (IUGR). To determine if PLAGL1 and HYMAI, two imprinted transcripts deregulated in Transient Neonatal Diabetes Mellitus, are involved in non-syndromic IUGR we compared the expression and DNA methylation levels in a large cohort of placental biopsies from I

SUBMITTER: Iglesias-Platas I 

PROVIDER: S-EPMC4334785 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature