Identification of a metastasis-specific MicroRNA signature in human colorectal cancer.

ABSTRACT:

Background

Distant metastasis is the major cause of mortality in colorectal cancer (CRC). We performed a systemic, comprehensive discovery for expression patterns of metastasis-specific microRNAs (miRNAs) by directly comparing primary CRCs (pCRCs) and matched liver metastases (LMs) and evaluated the feasibility of their clinical application as metastasis-specific biomarkers.

Methods

CRC metastasis-specific miRNA profiles were generated by analyzing nine pairs of pCRC and LM tissues, followed by quantitative validation in an independent cohort of 58 pairs of matched pCRC and LM tissues. We evaluated associations between miRNA expression and patient survival and ability to predict metastasis in another 84 patients with CRC. Subsequently, associations were quantitatively valida

SUBMITTER: Hur K 

PROVIDER: S-EPMC4334826 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature