Enriched environment-induced maternal weight loss reprograms metabolic gene expression in mouse offspring.

ABSTRACT: The global prevalence of weight loss is increasing, especially in young women. However, the extent and mechanisms by which maternal weight loss affects the offspring is still poorly understood. Here, using an enriched environment (EE)-induced weight loss model, we show that maternal weight loss improves general health and reprograms metabolic gene expression in mouse offspring, and the epigenetic alterations can be inherited for at least two generations. EE in mothers induced weight loss and its associated physiological and metabolic changes such as decreased adiposity and improved glucose tolerance and insulin sensitivity. Relative to controls, their offspring exhibited improved general health such as reduced fat accumulation, decreased plasma and hepatic lipid levels, and improved glucos

SUBMITTER: Wei Y 

PROVIDER: S-EPMC4335202 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature