Genetic associations of Nrf2-encoding NFE2L2 variants with Parkinson's disease - a multicenter study.

ABSTRACT:

Background

The transcription factor Nrf2, encoded by the NFE2L2 gene, is an important regulator of the cellular protection against oxidative stress. Parkinson's disease is a neurodegenerative disease highly associated with oxidative stress. In a previously published study, we reported associations of NFE2L2 haplotypes with risk and age at onset of idiopathic Parkinson's disease in a Swedish discovery material and a Polish replication material. Here, we have extended the replication study and performed meta-analyses including the Polish material and four new independent European patient-control materials. Furthermore, all SNPs included in the haplotype windows were investigated individually for associations with Parkinson's disease in meta-analyses including all six materials.

Me

SUBMITTER: von Otter M 

PROVIDER: S-EPMC4335439 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature