A Novel Reduction Strategy of Clarithromycin Resistance in Helicobacter pylori.

ABSTRACT:

Background

Antibiotic resistance is a major therapeutic problem in patients infected with Helicobacter pylori. H. pylori clarithromycin resistant mutants have been evolved during antibiotic therapy, this is mainly due to 23s rRNA point mutations.

Objectives

In the present study, we investigated anti-mutational features of four traditionally Iranian medicinal plants on three local isolated H. pylori strains.

Materials and methods

In this study clarithromycin resistance was used as a mutation indicator. Frequencies of such mutations in the presence and absence of plant extracts were evaluated. Mutation incidence was evaluated by Luria Delbruck fluctuation assay.

Results

The mean mutation frequency in H. pylori isolates was 27 × 10(-9) which decreased at the prese

SUBMITTER: Tadjrobehkar O 

PROVIDER: S-EPMC4335570 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature