Vitamin D receptor (VDR) polymorphisms and risk of ovarian cancer in Caucasian and African American women.

ABSTRACT:

Objective

Polymorphisms in the vitamin D receptor (VDR) gene have been shown in some studies to be associated with the risk of epithelial ovarian cancer (EOC) in Caucasian women. There are no published reports among African Americans.

Methods

Case-control data from the North Carolina Ovarian Cancer Study were analyzed using logistic regression to determine the association between seven VDR polymorphisms and EOC in both Caucasians (513 cases, 532 controls) and African Americans (74 cases, 79 controls). In a larger sample of African-Americans (125 cases, 155 controls), we assessed associations between six SNPs in proximity of rs7975232.

Results

African American women who carried at least one minor allele of rs7975232 were at higher risk for invasive EOC controlling for

SUBMITTER: Grant DJ 

PROVIDER: S-EPMC4335727 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature