Absence of neurocognitive effect of hepatitis C infection in HIV-coinfected people.

ABSTRACT:

Objective

To investigate the effect of hepatitis C virus (HCV) on neurocognitive performance in chronically HIV-infected patients enrolled in the CNS HIV Antiretroviral Therapy Effects Research (CHARTER) study.

Methods

A total of 1,582 participants in CHARTER who were tested for HCV antibody underwent neurocognitive testing; serum HCV RNA was available for 346 seropositive patients. Neurocognitive performance was compared in 408 HCV-seropositive and 1,174 HCV-seronegative participants and in a subset of 160 seropositive and 707 seronegative participants without serious comorbid neurologic conditions that might impair neurocognitive performance, using linear regression and taking into account HIV-associated and demographic factors (including IV drug use) and liver function.

SUBMITTER: Clifford DB 

PROVIDER: S-EPMC4335996 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature