Double-blind, randomized, controlled, crossover trial of pregabalin for neurogenic claudication.

ABSTRACT:

Objectives

To test the effects of pregabalin on the induction of neurogenic claudication.

Methods

This study was a randomized, double-blind, active placebo-controlled, 2-period, crossover trial. Twenty-nine subjects were randomized to receive pregabalin followed by active placebo (i.e., diphenhydramine) or active placebo followed by pregabalin. Each treatment period lasted 10 days, including a 2-step titration. Periods were separated by a 10-day washout period, including a 3-day taper phase after the first period. The primary outcome variable was the time to first moderate pain symptom (Numeric Rating Scale score ≥4) during a 15-minute treadmill test (Tfirst). Secondary outcome measures included pain intensity at rest, pain intensity at the end of the treadmill test, distanc

SUBMITTER: Markman JD 

PROVIDER: S-EPMC4335998 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature