Optimal achieved blood pressure in acute intracerebral hemorrhage: INTERACT2.

ABSTRACT:

Objectives

To investigate the effects of intensive blood pressure (BP) lowering according to baseline BP levels and optimal achieved BP levels in patients with acute intracerebral hemorrhage (ICH).

Methods

INTERACT2 was an open, blinded endpoint, randomized controlled trial in 2,839 patients with ICH within 6 hours of onset and elevated systolic BP (SBP) (150-220 mm Hg) who were allocated to receive intensive (target SBP <140 mm Hg within 1 hour, with lower limit of 130 mm Hg for treatment cessation) or guideline-recommended (target SBP <180 mm Hg) BP-lowering treatment. Outcome was physical function across all 7 levels of the modified Rankin Scale at 90 days.

Results

Analysis of the randomized comparisons showed that intensive BP lowering produced comparable benefits

SUBMITTER: Arima H 

PROVIDER: S-EPMC4336065 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature