Relationships between quantitative spinal cord MRI and retinal layers in multiple sclerosis.

ABSTRACT:

Objective

To assess relationships between spinal cord MRI (SC-MRI) and retinal measures, and to evaluate whether these measures independently relate to clinical disability in multiple sclerosis (MS).

Methods

One hundred two patients with MS and 11 healthy controls underwent 3-tesla brain and cervical SC-MRI, which included standard T1- and T2-based sequences and diffusion-tensor and magnetization-transfer imaging, and optical coherence tomography with automated segmentation. Clinical assessments included visual acuity (VA), Expanded Disability Status Scale, MS functional composite, vibration sensation threshold, and hip-flexion strength. Regions of interest circumscribing SC cross-sections at C3-4 were used to obtain cross-sectional area (CSA), fractional anisotropy (FA), pe

SUBMITTER: Oh J 

PROVIDER: S-EPMC4336102 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature