Inflammation, negative nitrogen balance, and outcome after aneurysmal subarachnoid hemorrhage.

ABSTRACT:

Objective

To analyze the impact of inflammation and negative nitrogen balance (NBAL) on nutritional status and outcomes after subarachnoid hemorrhage (SAH).

Methods

This was a prospective observational study of SAH patients admitted between May 2008 and June 2012. Measurements of C-reactive protein (CRP), transthyretin (TTR), resting energy expenditure (REE), and NBAL (g/day) were performed over 4 preset time periods during the first 14 postbleed days (PBD) in addition to daily caloric intake. Factors associated with REE and NBAL were analyzed with multivariable linear regression. Hospital-acquired infections (HAI) were tracked daily for time-to-event analyses. Poor outcome at 3 months was defined as a modified Rankin Scale score ≥ 4 and assessed by multivariable logistic re

SUBMITTER: Badjatia N 

PROVIDER: S-EPMC4336106 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature