Adjuvant chemotherapy for t1 node-positive colon cancers provides significant survival benefit.

ABSTRACT:

Background

Contemporary treatment of node-positive (N+) colon cancer consists of adjuvant chemotherapy; however, randomized data supporting this practice were derived from lesions T2 or greater. Minimal data exist regarding the use and need for adjuvant chemotherapy in T1N+ disease.

Objective

The aim of this study was to determine treatment trends and the effects of adjuvant chemotherapy on T1N+ colon cancers by using the National Cancer Database.

Design

This was a retrospective study. Baseline demographics, tumor, and cancer treatment characteristics were compared. Groups were matched on the propensity to receive chemotherapy. Adjusted long-term survival stratified by chemotherapy use was compared by using the Kaplan-Meier method with the log-rank test. Predictors of

SUBMITTER: Ganapathi AM 

PROVIDER: S-EPMC4336178 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature