Correlates of age at attainment of developmental milestones in HIV-infected infants receiving early antiretroviral therapy.

ABSTRACT:

Background

Infant HIV-1 infection is associated with impaired neurologic and motor development. Antiretroviral therapy (ART) has the potential to improve developmental outcomes but the relative contributions of pre-ART disease status, growth, treatment regimen and ART response during infancy are unknown.

Methods

Kenyan ART-naive infants <5-months old initiated ART and had monthly assessment of age of full neck control, unsupported walking and monosyllabic speech during 24 months of follow-up. Pre-ART and post-ART correlates of age at milestone attainment were evaluated using t tests or multivariate linear regression.

Results

Among 99 infants, pre-ART correlates of later milestone attainment included: underweight and stunted (neck control, walking and speech, all P val

SUBMITTER: Benki-Nugent S 

PROVIDER: S-EPMC4336221 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature