Validation of a continuous infusion of low dose Iohexol to measure glomerular filtration rate: randomised clinical trial.

ABSTRACT:

Introduction

There is currently no accurate method of measuring glomerular filtration rate (GFR) during acute kidney injury (AKI). Knowledge of how much GFR varies in stable subjects is necessary before changes in GFR can be attributed to AKI. We have designed a method of continuous measurement of GFR intended as a research tool to time effects of AKI. The aims of this crossover trial were to establish accuracy and precision of a continuous infusion of low dose Iohexol (CILDI) and variation in GFR in stable volunteers over a range of estimated GFR (23-138 mL/min/1.73 m(2)).

Methods

We randomised 17 volunteers to GFR measurement by plasma clearance (PC) and renal clearance (RC) of either a single bolus of Iohexol (SBI; routine method), or of a continuous infusion of low dose

SUBMITTER: Dixon JJ 

PROVIDER: S-EPMC4336474 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature