HIV-1 transmitted drug resistance mutations among antiretroviral therapy-Naive individuals in Surabaya, Indonesia.

ABSTRACT:

Background

The emergence of transmitted drug resistance (TDR) compromises the effect of antiretroviral therapy (ART), resulting in treatment failure of human immunodeficiency virus (HIV) disease. Although more than a decade has passed since ART was introduced into Indonesia, information on TDR is limited. Here, a genotypic study of TDR among ART-naïve individuals was conducted in Surabaya, Indonesia.

Method

HIV-1 seropositive participants were recruited from the communities of commercial sex workers and intravenous drug users as well as from the university teaching hospital in Surabaya. Protease (PR) and reverse transcriptase (RT) genes were sequenced in order to conduct HIV-1 subtyping and phylogenetic analysis and to detect TDR. TDR was defined as the presence of at least

SUBMITTER: Kotaki T 

PROVIDER: S-EPMC4336490 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature